Genetically engineered mice in medical research has been in use since considerably long time already and the number is expected to rise systematically further with ensuing investments in R&D and continued rise in several chronic ailments often leading to mortality and morbidity.

It is estimated that with substantial rise in adoption of personalized medicines targeting hard to cure diseases, adoption of humanized mouse and rat models is likely to witness greater adoption fetching substantial growth as a result. humanized mice and rat models offer much more dependable results

Genetically engineered mice in medical research has been in use since considerably long time already and the number is expected to rise systematically further with ensuing investments in R&D and continued rise in several chronic ailments often leading to mortality and morbidity.

It is estimated that with substantial rise in adoption of personalized medicines targeting hard to cure diseases, adoption of humanized mouse and rat models is likely to witness greater adoption fetching substantial growth as a result. humanized mice and rat models offer much more dependable results with high scale accuracy in terms of data, pertaining to human gene functionalities.

Several studies suggest that mice and rats prove to be the most commonly adopted animal models to effectively study patterns of human diseases and their appropriate therapeutics. It is rather intriguing to understand and perceive that rodents remain by far the most commonly used animals for laboratory research endeavors related to human diseases and their medication owing to their close similarity to biological, genetic and behavioral traits.

Growing Burden of Neuro-degenerative Ailments such as Parkinson’s and Alzheimer’s Encourage Reliance

This enables exact replication of the symptoms noticed in humans amongst mice and rats, thus further encouraging large scale adoption and subsequent growth in humanized mouse and rat models market. Replication of human specific ailments in rodents is seamlessly carried out by the simple method of modifying mouse genome that enables testing of improved therapeutic methods such as combinational drugs, also averting all possible damage of human health.

Degrative diseases, in particular related to neurological ailments such as central and peripheral nervous systems has been affecting geriatric population in multiple ways, with soaring instances of Parkinson's , motor neuron ailments as well as Alzheimer's enumerated as some of the riskiest as medication for these diseases remain deficient with no disease management practices. Ongoing researches are underway to develop therapeutic remedies, gene therapies as well as stem cell therapies.

Cellular and Genetic Humanization Remain Most Adopted Practices of Creating Human Genome in Rodents

At the backdrop of such disease burden, scientists and researchers are aggressively banking upon animal models such as humanized mouse and rat models to carry out vital R&D expeditions to crack pathogenic activities, decode drug targets, and the like, all in the interest of novel gene and cell therapies. Needless to mention, humanized mouse and rat models are increasingly gaining adoption in studying environmental and genetic parameters that contribute towards serious ailments, besides also developing accurate precision medicines to arrest the same.

Owing to stark differences in humans and mice, in terms of various factors such as anatomy, neuroanatomy, longevity, heart functionality as well as reproductive abilities, it is crucially vital to improve mouse genomes to suit laboratory experiments pertaining to developing precision medicines. Thus, developing humanized mouse and rat models automatically becomes a viable option which is achieved by inserting human DNA into mouse and rat genomes by the processes of genetic humanization and cellular humanization. Gene editing practices are witnessing sea change improvements over the years to accommodate new and improved mouse and rat models for advanced genetic studies. Unlike the previously used embryonic stem cell (ESC) methods for replicating human genes in animals. recently developed CRISPR gene editing method is evolving as a mainstream method of gene editing. The previous methodologies were limited as they were applicable only to mice.

Biocytogen Advances CRISPR Gene Editing with Flagship Mouse Model RenMab for Advanced Antibiotic Studies

However, the currently developed CRISPR gene editing method is applicable to both mice and rats. Leading participants in humanized mouse and rat models market are investing significantly in untapping novel opportunities in CRISPR gene editing methods. Technologies such as Extreme Genome Editing are novel additions that is designed to meet over twenty times better results for developing customized cell lines and improved humanized mice and rat models. This is advantageous in reducing the time frame required for developing improved humanized animal models with improved results.

In its recent advancement in humanized mice and rat models, Biocytogen has successfully developed a human antibody mouse to study advances in antibodies development targeting several ailments that lack medical aid. This newly developed model ensures advances in antibody research. This recent development by Biocytogen under the brand, RenMab enables modification of bulk chromosomal fragments as well as replacement of mouse antibody genes with human chromosomes, thus enabling superlative humanization of rats and mouse models. RenMab is designed to enable large scale generation and screening of antibodies, thus furthering advances in pharmaceutical and biotechnology studies on the flagship platform, Extreme Genome Editing of Biocytogen.

Ailments such as Cancer, AIDS and Allergies are Routinely Studied with Humanized Mouse and Rat Models

Further in the ambit of CRISPR gene editing, new R&D initiatives from a team of researchers at the US based Nebraska Medical Center and Temple University have lately come up with substantial evidence pertaining to novel genetic editing technology, CRISPR.

Humanized rat and mouse models are increasingly witnessing large scale adoption in cancer research endeavors to fast track advances in cancer genes novel cancer therapies. IN cancer therapeutics, researchers are combining CRISPR and T cell therapy to destroy potential tumors or cancer-causing cells. Large scale prevalence of allergies is growing at unprecedented levels owing to constant exposure to industrialization as well as exposure to chemicals and fumes at work. Therefore, to accurately follow and unravel crucial details in studying the patterns of allergic reactions, which is done by studying various animal models such as humanized rats and mouse models that bear considerable similarity with human genome, or at least can be manipulated or genetically edited for hassle free scientific studies.